Byron has Crohn's disease is a chronic inflammatory condition of the gastrointestinal tract, often varying in severity and manifestation among individuals. Its pathogenesis is complex and not entirely understood, involving a multifaceted interplay of genetic predispositions, environmental triggers, and autoimmune responses. Common symptoms can include persistent abdominal pain, frequent diarrhoea, extreme fatigue, and unintended weight loss, which can significantly impact daily life.

The diagnosis of Crohn's disease typically requires a comprehensive evaluation, including imaging techniques like MRI or CT scans, laboratory blood tests for inflammatory markers, and endoscopic examinations to visualise and obtain tissue samples from the intestine. These methods help establish the specific location and extent of intestinal inflammation.

Management of Crohn's disease may encompass a range of treatment strategies tailored to each individual. Lifestyle and dietary modifications can play a crucial role, alongside pharmacological interventions such as corticosteroids, anti-inflammatory agents, and immunosuppressants to reduce inflammation and control the immune response. In more severe cases, surgical options may be necessary to remove damaged portions of the digestive tract.

Patients often experience a pattern of flares and periods of remission, necessitating ongoing monitoring and support from healthcare professionals. Engaging with patient communities can also provide valuable emotional and practical assistance, enhancing the overall management of the condition.

The challenges for Byrons’ trip will be vast during this trip. He will be in multiple different environments, pushing himself mentally and physically, and not able to eat his regular diet. To assist him with the changes, he has spent 6-months preparing and planning how to eat, sleep, and manage stress levels - all in an attempt to minimise the risk of a Crohn’s flare up, so he can complete this gruelling challenge.